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Understanding Nature. Improving Life
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Publications

SignaBlok > News & Publications > Publications
SignaBlok > News & Publications > Publications

SCHOOL PLATFORM

SCHOOL of nature: ligand-independent immunomodulatory peptides

Sigalov AB. Drug Discovery Today. 2020
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The SCHOOL of nature: IV. Learning from viruses

Sigalov AB. Self Nonself. 2010
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The SCHOOL of nature: III. From mechanistic understanding to novel therapies

Sigalov AB. Self Nonself. 2010
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The SCHOOL of nature: II. Protein order, disorder and oligomericity in transmembrane signaling

Sigalov AB. Self Nonself. 2010
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The SCHOOL of nature: I. Transmembrane signaling

Sigalov AB. Self Nonself. 2010
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Novel mechanistic insights into viral modulation of immune receptor signaling

Sigalov AB. Plos Pathog. 2009
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Immune cell signaling: a novel mechanistic model reveals new therapeutic targets

Sigalov AB. Trends Pharmacol Sci. 2006
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Multichain immune recognition receptor signaling: different players, same game?

Sigalov AB. Trends Immunol. 2004
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MACROPHAGE MODULATION

Pertussis

Triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to Bordetella pertussis inflammatory pathology

Gallop D, Scanlon K et al. Infect Immun. 2021
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Liver Disease

Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice

Tornai D, Furi I et al. Hepatol Commun. 2019
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Cancer and Sepsis

Targeting Tumor-Associated Macrophages to Radiosensitize Glioblastoma in a Mouse Model

Mark DJ, Ruggieri M et al. Int J Radiat Oncol Biol Phys. 2019
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Novel TREM-1 Inhibitors Attenuate Tumor Growth and Prolong Survival in Experimental Pancreatic Cancer

Shen ZT and Sigalov AB. Mol Pharm. 2017
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A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock

Sigalov AB. Int Immunopharmacol. 2014
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Retinopathy

Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy

Rojas MA, Shen ZT et al. Biochim Biophys Acta Mol Basis Dis. 2018
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Arthritis

Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis

Shen ZT and Sigalov AB. J Cell Mol Med. 2017
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SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J Mice

Shen ZT and Sigalov AB. Sci Rep. 2016
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MACROPHAGE IMAGING

Atherosclerosis

Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles

Shen ZT, Zheng S et al. PLoS One. 2015
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Nature-inspired nanoformulations for contrast-enhanced in vivo MR imaging of macrophages

Sigalov AB. Contrast Media Mol Imaging. 2014
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“SCHOOL”: Signaling Chain HOmoOLigomerization

This discovery opens new avenues for drug development with applications in many serious diseases.

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