TREM-1 and TREM-2 as Therapeutic Targets: Clinical Challenges and Perspectives
Sigalov AB. Front Immunol. 2024
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SCHOOL of nature: ligand-independent immunomodulatory peptides
Sigalov AB. Drug Discovery Today. 2020
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The SCHOOL of nature: IV. Learning from viruses
Sigalov AB. Self Nonself. 2010
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The SCHOOL of nature: III. From mechanistic understanding to novel therapies
Sigalov AB. Self Nonself. 2010
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The SCHOOL of nature: II. Protein order, disorder and oligomericity in transmembrane signaling
Sigalov AB. Self Nonself. 2010
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The SCHOOL of nature: I. Transmembrane signaling
Sigalov AB. Self Nonself. 2010
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Novel mechanistic insights into viral modulation of immune receptor signaling
Sigalov AB. Plos Pathog. 2009
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Immune cell signaling: a novel mechanistic model reveals new therapeutic targets
Sigalov AB. Trends Pharmacol Sci. 2006
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Multichain immune recognition receptor signaling: different players, same game?
Sigalov AB. Trends Immunol. 2004
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Scleroderma
Inhibiting Triggering Receptor Expressed on Myeloid Cells 1 Signaling to Ameliorate Skin Fibrosis
Bale et al. JCI Insight. 2024
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COVID-19
Pertussis
Triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to Bordetella pertussis inflammatory pathology
Gallop D, Scanlon K et al. Infect Immun. 2021
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Liver Disease
Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice
Tornai D, Furi I et al. Hepatol Commun. 2019
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Cancer and Sepsis
Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes
Pullikuth et al. Front Oncol. 2021
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Commentary: Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation
Sigalov AB. Front Immunol. 2020
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Targeting Tumor-Associated Macrophages to Radiosensitize Glioblastoma in a Mouse Model
Mark DJ, Ruggieri M et al. Int J Radiat Oncol Biol Phys. 2019
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Novel TREM-1 Inhibitors Attenuate Tumor Growth and Prolong Survival in Experimental Pancreatic Cancer
Shen ZT and Sigalov AB. Mol Pharm. 2017
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Retinopathy
Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy
Rojas MA, Shen ZT et al. Biochim Biophys Acta Mol Basis Dis. 2018
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Arthritis
Inhibition of TREM-2 markedly suppresses joint inflammation and damage in experimental arthritis
Sigalov AB. Int J Mol Sci. 2022
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Rationally designed ligand-independent peptide inhibitors of TREM-1 ameliorate collagen-induced arthritis
Shen ZT and Sigalov AB. J Cell Mol Med. 2017
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SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J Mice
Shen ZT and Sigalov AB. Sci Rep. 2016
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Atherosclerosis
Nature-inspired nanoformulations for contrast-enhanced in vivo MR imaging of macrophages
Sigalov AB. Contrast Media Mol Imaging. 2014
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